Acridine solubility
WebAmsacrine lacks broad spectrum clinical activity and is difficult to formulate because of its low aqueous solubility. It was thought that the relatively high p K a of the compound … WebACRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Acridine solubility
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Several dyes and drugs feature the acridine skeleton. Many acridines, such as proflavine, also have antiseptic properties. Acridine and related derivatives (such as amsacrine) bind to DNA and RNA due to their abilities to intercalate. Acridine orange (3,6-dimethylaminoacridine) is a nucleic acid-selective … See more Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with … See more Acridine displays the reactions expected of an unsaturated N-heterocycle. It undergoes N-alkylation with alkyl iodides to form alkyl acridinium iodides, which are readily transformed … See more Acridine is a skin irritant. Its LD50 (rats, oral) is 2,000 mg/kg and 500 mg/kg (mice, oral). See more • Moloney, Gerard P.; Kelly, David P.; Mack, P. (2001). "Synthesis of Acridine-based DNA Bis-intercalating Agents" (PDF). Molecules. 6 (3): 230–243. doi:10.3390/60300230 See more Carl Gräbe and Heinrich Caro first isolated acridine in 1870 from coal tar. Acridine is separated from coal tar by extracting with dilute sulfuric acid. Addition of potassium dichromate to this solution precipitates acridine bichromate. The bichromate is decomposed See more As established by X-ray crystallography, acridine has been obtained in eight polymorphs. All feature very similar planar molecules with … See more • Lucigenin, a chemiluminescent compound derived from acridine See more WebThe tricyclic acridine chromophore was originally developed (Harrison et al., 1999) as an alternative platform to the anthraquinones, in order to circumvent the poor aqueous solubility of many amidoanthraquinone derivatives.The central ring nitrogen atom in acridines such as 3,6-diaminoacridine (proflavine) is protonated at physiological pH …
WebAcridine orange is a nucleic acid selective fluorescent cationic dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions. ... Solubility: Soluble in DMSO. Shipping: Ambient Temperature : Long Term Storage:-20°C : Use/Stability: Stable for at least one year ... WebSolubility in Water: No data. Solubility Notes: ~1 mg/ml in PBS (pH 7.2); ~0.3 mg/ml in EtOH; ~20 mg/ml in DMSO; ~2 mg/ml in DMF; Octanol/Water Partition Coefficient: ... Acridine Orange - Investigated as a drug, mutagen, and tumorigen. Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here. ...
WebAcridine definition, a colorless, crystalline solid, C13H9N, usually obtained from the anthracine fraction of coal tar: used chiefly in the synthesis of dyes and drugs. See more. WebJan 1, 2024 · The introduction of a hydroxyl group in AUEA increased the solubility and helped in controlled dispersion while dyeing. Further, they were dyed on modacrylic fabric as high visibility fluorophores, ... Acridine orange base is one of the common acridine-based fluorescent dyes that was vastly documented in the literature [1,2]. They were widely ...
WebAcridine C13H9N CID 9215 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity …
WebAcridine orange is a fluorescent dye which easily traverses the cell membrane. Because of its weak basic property, it accumulates in lysosomes, which have a low pH inside, due to an ATP-dependent proton pump, present in their membrane. Once inside, the dye is protonated and becomes, by this, entrapped in these organelles (D3). edl north carolinaWebAcridine Orange, 10 mg/mL in Water (High Purity) (AO) Acridine orange (AO) stains dsDNA green (525 nm) and RNA or single stranded DNA red (650 nm). The dye is membrane-permeant and its nucleic acid binding … edln scoutWebSolubility Data for Acridine Orange hydrochloride Solubility Soluble to 10 mg/ml in water Product Datasheets for Acridine Orange hydrochloride Certificate of Analysis / Product Datasheet Select another batch: View Batch Safety Datasheet References for Acridine Orange hydrochloride edl military acronymWebAcridine orange is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of acridine orange in these solvents is approximately 0.3, 20, … cons of tube microphonesWebresearch, the solubility of Acridine in supercritical CO 2 was measured using a static method. The solubility was measured for at least three times and the percent relative standard deviations in the range of 2-6% were obtained. In this study, the experimental solubility data of Acridine were correlated using e d locks \u0026 securityWebJul 3, 2002 · The fluorophore 10 N-nonyl acridine orange (NAO) has been reported as binding tightly to the phospholipid cardiolipin ( Petit et al. 1992 ), which is found exclusively in mitochondrial membranes in eukaryotes and bacteria (for a review see Schlame et al. 2000 ). ed loarWebAmsacrine lacks broad spectrum clinical activity and is difficult to formulate because of its low aqueous solubility. It was thought that the relatively high p K a of the compound (8.02 for the acridine nitrogen) was important in limiting in vivo distribution; consequently, analogs with improved solubility and high DNA binding, but with lower p ... ed loan login