Cisplatin livertox
WebThe DILIrank dataset consists of 1,036 FDA-approved drugs that are divided into four classes according to their potential for causing drug-induced liver injury (DILI). The DILI classification is ... WebMay 18, 2024 · Cisplatin (cis-diamminedichloroplatinum; CP) is an effective alkylating and antineoplastic agent that is widely used in the treatment of solid tumors. 1 The liver is a key organ in the metabolism and detoxification of endobiotics and xenobiotics. 2 CP is accumulated in liver cells, leading to hepatotoxicity.
Cisplatin livertox
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WebCisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been … WebMay 7, 2024 · Corticosteroids - LiverTox - NCBI Bookshelf The corticosteroids are a group of chemically related natural hormones and synthetic agents that resemble the human adrenal hormone cortisol and have potent antiinflammatory and immunosuppressive properties and are widely used in medicine.
WebSep 15, 2024 · Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL multiple dose … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …
WebMar 9, 2024 · A typical dosing regimen is 30 minute infusions of 1.0 to 1.2 g/m 2 on days 1, 8 and 15 of each 28 day cycle of chemotherapy. Common side effects include bone marrow suppression, fatigue, diarrhea, nausea, … WebCarboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue.This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich …
WebCisplatin Vial. - Uses, Side Effects, and More. Cisplatin may cause severe kidney problems, nerve problems, and severe nausea and vomiting. Nerve problems may occur …
WebMar 30, 2024 · LiverTox®provides up-to-date, unbiased and easily accessed information on the diagnosis, cause, frequency, clinical patterns and management of liver injury … photo frame 4 x 3WebJun 23, 2024 · Durvalumab is a human monoclonal antibody to programmed cell death ligand 1 (PD-L1), which acts as a checkpoint inhibitor and is used in the immunotherapy of several forms of advanced … photo frame 2 photosWebNov 20, 2024 · Drug induced liver injury is an uncommon but important and challenging form of liver disease. When evaluating a patient with new-onset liver disease, drugs, including prescription drugs, over-the-counter preparations, dietary supplements, vitamins and herbal medications, must always be considered as a possible cause. Indeed, the possibility … how does food access affect healthWebDec 20, 2024 · The interrelationship between the liver and molecularly targeted agents used for cancer therapy are discussed elsewhere, as is hepatotoxicity associated with checkpoint inhibitor immunotherapy, as used for advanced melanoma and other solid tumors. how does fomc affect forexWebCisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been … how does food affect college studentsWebCisplatin, doxorubicin and fluorouracil (5-FU), drugs belonging to different chemical classes, have been extensively used for chemotherapy of various cancers. Despite extensive investigations into their hepatotoxicity, there is very limited information on their effects on the structure and ultra-structure of liver cells in vivo. photo frame 3x5WebJun 3, 2024 · LiverTox has two major components: 1) an introduction and overview of drug-induced liver injury that includes discussions of clinical patterns, diagnostic criteria, and … how does food affect blood glucose levels