WebFeb 1, 2024 · Interestingly, we found by FISH unexpected ALK gene amplifications (mean value 42%) in two cases and high prevalence of polysomy in three cases (mean value 72.6%) together with ALK rearrangement. These complex rearranged cases were not detectable by IHC probably because of a lack of fusion protein expression. WebThe data also demonstrated that the average chromosome 17 copy number in FISH-positive tumors (n = 135) overall was significantly higher than that in FISH-negative tumors (n = 426) (2.27 vs. 1.70; P < 0.0001), indicating that polysomy 17 was more commonly seen in tumors with Her-2/neu gene amplification.
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WebDec 23, 2009 · FISH trisomy/tetrasomy-positive results have very limited implications in PSC patients. A positive FISH polysomy test result does enhance the sensitivity of cytology testing for CCA, especially if a … WebThe detection of multiple chromosomal gains by fluorescence in situ hybridization (FISH), referred to as polysomy, has demonstrated improved sensitivity over routine cytological … cynthia wilkinson attorney
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Fluorescence in situ hybridization (FISH) is a cytogenetic technique that has proven to be useful in the diagnosis of patients with polysomy. Conventional cytogenetics and fluorescence in situ hybridization (FISH) have been used to detect various polysomies, including the most common autosomies (trisomy 13, 18, 21) as well as polysomy X and Y. Testing for chromosomal aneuploidy with Fluorescence … WebOct 14, 2024 · A patient with a polysomy FISH result had a significantly higher risk of malignancy than a patient with a trisomy 7 result (82% vs. 32%, p < 0.00001). (1) Background: Although the specificity of brush cytology for the detection of malignant pancreaticobiliary strictures is high, its sensitivity is low. Fluorescence in situ … WebOur study aimed to evaluate the status of MDM2 and DDIT3 by FISH in liposarcoma and correlate it with diagnosis of different subtypes of liposarcoma. The subtypes of liposarcoma were classified according to the FISH results, combined with the relevant clinicopathological features. ... 2/10); DDIT3 polysomy detected by DDIT3 gene rearrangement ... cynthia whitney wand of fortune