He and klionsky fundc1

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August undefined, 2024

Web19 de ene. de 2024 · FUNDC1-knockdown HeLa cells were transfected with FUNDC1-myc for 24 h, and then with plasmids expressing the indicated mitochondria-associated E3 … Web8 de feb. de 2024 · Here we report that PGC-1α and nuclear respiratory factor 1 (NRF1), master regulators of mitochondrial biogenesis and metabolic adaptation, also …

FUNDC1 regulates mitochondrial dynamics at the …

Web9 de may. de 2024 · Here, we are aimed to explore the role of c-Src (Src) and FUNDC1-related mitophagy in the development of DN. Methods: The db/db mice were used to establish a DN mice model. The mice accepted PP2 (Src inhibitor) treatment to study the role of Src in DN. Kidney function was measured via biochemical testing. Web26 de mar. de 2014 · The mitophagy receptor FUNDC1 is a novel substrate of ULK1 and FUNDC1 (N118A) that prevents its binding to ULK1, impairs ULK1 translocation to mitochondria, and inhibits mitophagy A. HeLa cells … gulf of mexico birds

FUNDC1 - an overview ScienceDirect Topics

WebAn X-linked lysosomal storage disease marked by progressive symptoms including burning pain in the hands and feet, sweating, and purple skin lesions, with death resulting from … WebCongcong He 1 , Daniel J Klionsky Affiliation 1Life Sciences Institute and Departments of Molecular, Cellular and Developmental Biology, and Biological Chemistry, University of … WebDaniel J. Klionsky focuses on Cell biology, Autophagy, Vacuole, Lysosome and Biochemistry. His Cell biology research includes themes of Atg1 and Autophagy-Related Protein 8 Family. His Autophagy study frequently draws parallels with other fields, such as Programmed cell death. The Vacuole study combines topics in areas such as Protein … gulf of mexico boating

(PDF) Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia ...

WebTakeshi Noda 1 , Daniel J Klionsky. Affiliation 1 Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. PMID: 19185711 DOI: 10.1016/S0076-6879(08)03203-5 Abstract The measurement of ... Web19 de abr. de 2024 · FUNDC1是一种跨膜蛋白，位于线粒体外膜上，具有3个α螺旋，其中膜外的N端氨基序列中包含一段保守LIR，由此区域可以与LC3相互作用以介导低氧诱导的线粒体自噬[16]。正常情况下FUNDC1通过与内质网膜钙调蛋白的链接，在MAM处聚集；缺氧时FUNDC1/钙调蛋白的链接变弱，继而DRP1因与FUNDC1结合后被募集到MAM，线粒体 … gulf of mexico block map eugene islandhttp://fund.keyanzhiku.com/Index/info/id/NDI3NDE3MTYwYmllLXNoaS1sZS1xdS1iaWUtcmVuLWppYS1wYS1zaHUtanUtYmE%3D.html gulf of mexico beachfront rentals

"Web5 de abr. de 2010 · Klionsky eventually left his home state in 2000, moving to the University of Michigan's Life Sciences Institute where he has continued to study autophagy in yeast, recently uncovering proteins that target damaged mitochondria for degradation ( 5 ). " - He and klionsky fundc1

He and klionsky fundc1

Frontiers Research Progress on the Mechanism of Mitochondrial ...

Web5 de abr. de 2024 · As a key receptor of mitophagy, FUNDC1 also plays an important role in many kinds of human diseases, especially in cardiovascular diseases. In obese mice …

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WebFUNDC1 驻留在线粒体外膜蛋白上，调节线粒体动力学和缺氧诱导的线粒体吞噬 (2-4)。它包含一个氨基末端 LC3 相互作用区 (LIR)，负责与 LC3 相连并将线粒体募集到自噬体。 FUNDC1 的磷酸化状态可以通过影响其与 LC3 的结合来调节其活性 (4-6）。在正常条件下，FUNDC1 在 Tyr18 处被 Src 磷酸化，这在缺氧过程中被抑制，从而导致去磷酸化 (4)。 … Web10 de may. de 2024 · FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-membrane protein, and mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs). This ...

WebDOI: 10.1016/S1534-5807(03)00402-7 Corpus ID: 20852046; The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. @article{Reggiori2004TheAC, title={The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure.}, author={Fulvio M Reggiori … Web12 de abr. de 2024 · Abstract. This study aimed to determine if there is an association between mitophagy and refractory temporal lobe epilepsy (rTLE) with hippocampal sclerosis. During epilepsy surgery, we collected tissue samples from the hippocampi and temporal lobe cortexes of rTLE patients with hippocampal sclerosis (as diagnosed by a pathologist).

http://www.chinaqking.com/yc/2024/1114771.html Web29 de feb. de 2012 · He C, Klionsky DJ. Regulation mechanisms and signaling . pathways of autophagy. Annu Rev Genet 2009;43:67-93. He C, Levine B. The Beclin 1 interactome. Curr Opin Cell Biol . 2010;22:140-9.

Web5 de abr. de 2010 · Before that, Klionsky, a California native, was a biology major at UCLA and a graduate student at Stanford, investigating the bacterial ATP synthase with Bob …

WebDaniel Klionsky, Ph.D. Research Professor, Life Sciences Institute Alexander G. Ruthven Professor of Life Sciences, Department of Molecular, Cell & Developmental Biology, U-M College of Literature, Science, and the Arts (734) 615-6556 [email protected] Research Staff Hana Popelka, Ph.D. Research Laboratory Specialist [email protected] gulf of mexico blacktip sharkWeb16 de dic. de 2024 · In addition, FUNDC1 can be enriched at contact sites between mitochondria and the endoplasmic reticulum (ER), determining the formation of mitochondria-associated membranes (MAMs) that regulate cellular calcium (Ca 2+) homeostasis and mitochondrial dynamics to prevent heart dysfunction. gulf of mexico bouy reportsWebDaniel Klionsky, Ph.D. Research Professor, Life Sciences Institute Alexander G. Ruthven Professor of Life Sciences, Department of Molecular, Cell & Developmental Biology, U-M College of Literature, Science, and … gulf of mexico boat trackerWeb10 de dic. de 2024 · FUNDC1 is a new OMM protein that promotes mitochondrial fragmentation and mitophagy during hypoxia ( Liu et al., 2012; Zhang et al., 2016a; … bowflex heart rate chest strap batteryWebAnalyzing autophagy in zebrafish Analyzing autophagy in zebrafish Authors Congcong He 1 , Daniel J Klionsky Affiliation 1 Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. PMID: 20495344 PMCID: PMC3654832 DOI: 10.4161/auto.6.5.12092 Abstract gulf of mexico blocks mapWeb5 de dic. de 2024 · FUNDC1 was initially reported to stimulate mitophagy in response to hypoxia. 9 This protein binds to LC3 proteins and operates as an autophagy receptor, and its activity is stimulated by phosphorylation catalyzed by ULK1 10 or by dephosphorylation by PGAM5. 10 In addition, FUNDC1 has been documented to accumulate at … gulf of mexico beach vacationWeb10 de may. de 2024 · FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-membrane protein, and mediates the formation of mitochondria … gulf of mexico boem